Successful treatment of optic neuropathy in association with systemic lupus erythematosus using intravenous cyclophosphamide
Oregon Health Sciences University, Casey
Eye Institute, Portland, Oregon, USA
Correspondence to: J T Rosenbaum, MD, Oregon Health Sciences University, Casey Eye Institute, 3375 SW Terwilliger Blvd, Portland, OR 97201, USA.
Accepted for publication 14 October 1996
BACKGROUND
Optic neuropathy is a rare
manifestation of systemic lupus erythematosus (SLE). In a previous
series most patients with optic neuropathy in association with SLE had
a final visual acuity of 20/200 or less despite corticosteroid therapy.
METHODSThree patients (five affected eyes) with
severe retrobulbar optic neuropathy in association with SLE were
treated promptly with intravenous cyclophosphamide and corticosteroids.
RESULTSAll patients recovered excellent visual acuity.
CONCLUSIONAlthough optic neuropathy in
association with SLE might have several different aetiologies,
intravenous cyclophosphamide should be strongly considered as a
therapeutic alternative.
© 1997 by British Journal of Ophthalmology
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