Trabeculectomy with intraoperative sponge 5-fluorouracil in Afro-Caribbeans
The Western Eye Hospital, Marylebone Road, London NW1
5YE
Correspondence to: C Migdal.
Accepted for publication 26 March 1997
AIM
To study the efficacy and safety of
intraoperative 5-fluorouracil (5-FU) in Afro-Caribbean patients.
METHODSThe results of trabeculectomy in 18 eyes
of 18 Afro-Caribbean patients in whom a sponge soaked in 25 mg/ml
solution of 5-FU was applied between Tenon's capsule and sclera for
5 minutes before excision of the trabecula were compared with 16 eyes
of 16 Afro-Caribbean patients matched for age, quantity, and duration
of preoperative medications, who underwent trabeculectomy without 5-FU.
RESULTSThe mean postoperative intraocular
pressure (IOP) at 1 month was 15.6 (SD 6.1) mm Hg in the 5-FU group and
18.0 (5.2) mm Hg in the control group (p=0.15). There was no
significant difference in the IOP at 6, 12, 15, 18, and 24 months in
the two groups. Success rate at 18 months defined as an IOP less than
or equal to 21 mm Hg with no adjunctive medication was 56% in the 5-FU group and 55% in the control group. No major complications were noted
in either group.
CONCLUSIONIntraoperative sponge 5-FU alone is
safe but does not appear to decrease the risk of failure of
trabeculectomy in Afro-Caribbeans.
© 1997 by British Journal of Ophthalmology
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This article has been cited by other articles:
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(2000). Sponge delivery variables and tissue levels of 5-fluorouracil. Br. J. Ophthalmol.
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