Br J Ophthalmol 1997;81:559-562 ( July )

Incidence and survival of retinoblastoma in the Netherlands: a register based study 1862-1995

Annette C Moll,^a D Joop Kuik,^b Lex M Bouter,^b Willem Den Otter,^c P Dick Bezemer,^b Jan Willem Koten,^c Saskia M Imhof,^a Bertus P Kuyt,^d Karel E W P Tan^a

^a Department of Ophthalmology, Vrije Universiteit, Amsterdam, Netherlands, ^b Department of Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam, Netherlands, ^c Department of Functional Morphology, Utrecht University, Netherlands, ^d Department of Human Genetics, Vrije Universiteit, Amsterdam, Netherlands

Correspondence to: A C Moll, MD, Department of Ophthalmology, Free University Hospital, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands.

Accepted for publication 11 March 1997

AIMThe aim of this study was to determine the (time trends in) incidence and survival of hereditary (familial and sporadic) and non-hereditary retinoblastoma for male and female patients born in the Netherlands between 1862 and 1995.
METHODThe national retinoblastoma register was updated and now consists of 955 patients. The missing dates of death were obtained from the municipal registers and the Central Bureau of Genealogy in The Hague. Mortality was compared with the Dutch vital statistics.
RESULTSFrom 1862 to 1995 no significant differences in incidence for retinoblastoma were found in the hereditary subgroups. Further, no significant differences between males and females were found, both overall and in the hereditary subgroups. The average incidence of retinoblastoma increased untill 1944, probably due to incompleteness of the register, and stabilised after 1945 (1 per 17 000 live births). From 1900 to 1995 the standardised mortality ratio increased for hereditary retinoblastoma patients from 2.9 to 9.0 and decreased for non-hereditary retinoblastoma patients from 1.9 to 1.0.
CONCLUSIONAlthough survival for retinoblastoma was significantly better after 1945 than before, in comparison with the Dutch population the mortality between 1900 and 1990 increased for the hereditary and decreased for the non-hereditary retinoblastoma patients.

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© 1997 by British Journal of Ophthalmology
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