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British Journal of Ophthalmology 1997;81:595-598; doi:10.1136/bjo.81.7.595
Copyright © 1997 by the BMJ Publishing Group Ltd.
Br J Ophthalmol 1997;81:595-598 ( July )

Human papilloma virus in neoplastic and non-neoplastic conditions of the external eye

Zeynel A Karcioglu,a b Tawfik M Issaa

a King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia, b Tulane University Medical School, New Orleans, LA, USA

Correspondence to: Zeynel A Karcioglu, MD, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Kingdom of Saudi Arabia.

Accepted for publication 18 March 1997

AIM---Human papilloma virus (HPV) types 16 and 18 have been associated with neoplastic conditions of the conjunctiva. However, the presence of this virus has not been reported in non-neoplastic disorders of the external eye nor has it been studied in normal conjunctival tissues.
METHODS---Ninety six paraffin embedded tissue specimens with neoplastic and non-neoplastic lesions and 19 conjunctiva samples free from overt disease were studied for HPV types 16 and 18 positivity with the polymerase chain reaction.
RESULTS---HPV types 16 and 18 DNA were identified in 57% of in situ squamous cell carcinoma, in 55% of invasive squamous cell carcinoma, in 20% of climatic droplet keratopathy, in 35% of scarred corneas, and in 32% of normal conjunctival tissue obtained during routine cataract extractions.
CONCLUSION---These findings indicate that HPV types 16 and 18 are detectable with the polymerase chain reaction not only in epithelial neoplasms of the ocular mucous membrane but also in non-neoplastic lesions as well as in apparently healthy conjunctiva.

© 1997 by British Journal of Ophthalmology
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