Diseases associated with ocular surface abnormalities: the importance of reflex tearing
a Department of
Ophthalmology, Tokyo Dental College, Chiba, Japan, b Department of Ophthalmology, Keio University
School of Medicine, Tokyo, Japan
Correspondence to: Kazuo Tsubota, MD, Department of Ophthalmology, Tokyo Dental College, 11-13 Sugano 5 Chome, Ichikawa-shi, Chiba, Japan 272-8513.
Accepted for publication 5 August 1998
AIM
To investigate the
correlation between tear function tests and ocular surface integrity in
patients with dry eye.
METHODS297 dry eye
patients (55 Sjögren's syndrome, two male and 53 female, average age
52.4 (SD 15.0) years, and 242 non-Sjögren's syndrome, 41 male and
201 female, average age 53.5 (14.1) years) were examined. The following
tear function tests were performed: (1) cotton thread test, (2)
Schirmer test with topical anaesthesia, (3) Schirmer test without
anaesthesia, (4) Schirmer test with nasal stimulation, (5) tear
clearance test, and (6) tear break up time (BUT). The ocular surface
was evaluated by rose bengal and fluorescein staining. Correlation
analysis was performed between each tear function index and vital
staining scores.
RESULTSAmong the six
tear function tests, the Schirmer test with nasal stimulation
correlated most with both of the vital stains (
=0.530 for rose
bengal and 0.393 for fluorescein). The Schirmer test with or without
anaesthesia correlated slightly with rose bengal staining, whereas tear
clearance test and tear break up time slightly correlated with
fluorescein staining.
CONCLUSIONVital
staining of the ocular surface correlates most with reflex tearing
measured by the Schirmer test with nasal stimulation.
© 1999 by British Journal of Ophthalmology
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