Scientific correspondence
CD56+ T cells in the peripheral blood of uveitis patients
Hitoshi Yatoa, Yoshihiro Matsumotob
a Department of
Ophthalmology, Nagoya University School of Medicine, Japan, b Department of Haematology, Chukyo Hospital,
Japan
Correspondence to: H Yato, Department of Ophthalmology, Nagoya University School of Medicine, 65 Tsuruma-Cho, Showa-ku, Nagoya 466-8550, Japan
Accepted for publication 11 August 1999
AIMS
Natural killer T
(NKT) cells, T lymphocytes expressing both T cell and NK cell markers,
are suggested to be involved in autoimmune diseases. To examine the
relation between the pathogenesis of uveitis and CD56+ T cells, which
are thought to be a type of human NKT cells, we investigated peripheral
CD56+ T cells in uveitis patients.
METHODS41 uveitis
patients (Behçet's disease (BD), 14; sarcoidosis (SAR), eight;
Vogt-Koyanagi-Harada disease (VKH), five; idiopathic uveitis (IU),
nine; and others, five) and 19 healthy controls participated in this
study. Cell surface antigens of lymphocytes were analysed by use of
monoclonal antibodies and flow cytometry.
RESULTSThe proportion
of CD56+ T cells in patients with BD was higher than in controls and in
patients with SAR, VKH, IU, and others.
CONCLUSIONIncreased
peripheral CD56+ T cells might be relevant to the pathogenesis of
uveitis in BD, and increase of peripheral CD56+ T cells may be one of
the laboratory findings to suggest that uveitis originates from BD.
© 1999 by British Journal of Ophthalmology
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