Pilot study of the multifocal electroretinogram in ocular hypertension
Henry H L Chan, Brian Brown
Department of
Optometry and Radiography, Hong Kong Polytechnic University, Hong Kong
Correspondence to: Dr Chan orhenry{at}polyu.edu.hk
Accepted for publication 26 April 2000
AIMS
To investigate
the variation of retinal function in ocular hypertension (OHT) using
the multifocal electroretinogram (MERG), that can objectively assess
regional retinal responses using kernel analysis.
METHODSPatients with
OHT were recruited for 61 flash MERG recording. The first and second
order kernel responses were analysed and compared with responses from a
normal group. All the patients with OHT had full eye examinations and
visual field analysis to ensure they had no ocular pathology, apart
from high IOP (
22 mm Hg).
RESULTSIn OHT, both
the first and the second order kernel responses showed a reduction in
magnitude compared with control values. The second order kernel
responses showed larger relative reduction of amplitude than the first
order responses. In addition, the macula showed a greater reduction in
response than the periphery.
CONCLUSIONSFirst
order and second order kernel analyses are useful for detecting changes
of retinal response in OHT. The second order kernel analysis is
important in measuring the inner retinal activity and is an important
factor in detecting the early glaucoma case. Diminished macular
response may be a useful sign in early glaucomatous changes.
© 2000 by British Journal of Ophthalmology
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