Mooren's ulcer in China: a study of clinical characteristics and treatment
Jiaqi Chen, Hanping Xie, Zhen Wang, Bing Yang, Zuguo Liu, Longshan Chen, Xiangming Gong, Yuesheng Lin
Zhongshan
Ophthalmic Center, Sun Yat-sen University of Medical Sciences,
Guangzhou, PR China
Correspondence to: Dr Jiaqi Chen, Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, PR China zoc{at}gzsums.edu.cn
Accepted for publication 8 May 2000
AIMS
To investigate
the clinical characteristics and compare the effects of several methods
of treatment of Mooren's corneal ulcer.
METHODS550
consecutive cases of Mooren's corneal ulcer were analysed in patients,
including age, sex, laterality of eye, ulcer location, perforative
rate, cure rate of surgeries, recurrent rate, the effects of
conjunctiva excision, lamellar keratoplasty (LKP), and LKP plus 1%
cyclosporin A eye drops.
RESULTSThe average
age of onset was 48.4 years of age. The ratio of males to females was
1:0.74. 165 (30%) cases had the disease bilaterally, of which 52 (31.5%) occurred in the young age group and 113 (68.5%) in the old
age group. Ulcers of 501 eyes (70.1%) were located at the limbus of
the palpebral fissure. The perforation rate was 13.3%, with
perforation of 41 eyes (43.2%) occurring in the young age group and 54 (56.8%) in the old age group. Postoperative recurrence rate was
25.6%. The cure rate of the first procedure of LKP plus 1%
cyclosporin A eye drops was 73.7%. The final cure rate was 95.6%, and
the postoperative preservation rate of the eye globe was 99.7%.
CONCLUSIONThis
primary study provided the clinical characteristics of patients with
Mooren's corneal ulcer in China. LKP plus 1% cyclosporin A eye drops
was an effective treatment.
© 2000 by British Journal of Ophthalmology
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