Discriminant analysis models for early detection of glaucomatous optic disc changes
Michele Iestera, Jost B Jonasb, Christian Y Mardinb, Wido M Buddeb
a Department
of Neurological and Visual Sciences, Ophthalmology B, University of
Genoa and Division of Ophthalmology of the Gaslini G Institute, Genoa,
Italy, b Department of
Ophthalmology and Eye Hospital, Friedrich-Alexander- University
Erlangen-Nürnberg, 91054 Erlangen, Germany
Correspondence to: Dr M Iester, Viale Teano 71/1, 16147 Genoa, Italy iester{at}csita.unige.it
Accepted for publication 13 January 2000
AIM
To evaluate and
compare four different mathematical formulas for the early detection of
morphometric optic nerve head changes in chronic open angle glaucoma.
METHODSThe optic
nerve heads of 161 patients with perimetrically defined glaucomatous
optic nerve damage and of 194 normal subjects were examined by confocal
laser scanning tomography. Using four formulas of linear discriminant
analysis and the optic cup shape measure as the single optic disc
variable, the predictive power of each of these methods was examined to
differentiate between the normal eyes and the glaucoma eyes.
RESULTSThe highest
predictive power had an optic disc sector based formula, in particular
in eyes with medium and large optic discs. This optic disc sector based
formula was the one with the best agreement with the other formulas
examined. It achieved a better predictability than any single optic
disc variable evaluated.
CONCLUSIONSCombining
quantitative optic disc variables by discriminant analysis functions,
the predictive power of semiautomatic quantitative optic nerve head
evaluation can be improved by providing the ophthalmologist with a
diagnostic score for the detection of glaucomatous optic nerve damage.
Because of the pattern of glaucomatous neuroretinal rim loss, an optic
disc sector based discriminant formula may have a higher diagnostic
precision than other formulas in detecting early glaucomatous damage.
© 2000 by British Journal of Ophthalmology
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