Scientific correspondence
The effect on intraocular pressure of latanoprost once or four
times daily
Christina Lindéna, Albert Almb
a Department of
Clinical Science, Ophthalmology, Umeå University, SE-901 85 Umeå,
Sweden, b Department of
Neuroscience, Ophthalmology, Uppsala University, SE-751 85 Uppsala,
Sweden
Correspondence to: C Lindén, Department of Clinical Science, Ophthalmology, Umeå University, SE-901 85 Umeå, Sweden christina.linden{at}ophthal.umu.se
Accepted for publication 4 April 2001
AIMS
To compare the
effect on intraocular pressure (IOP) of latanoprost applied once daily
with four times daily and to study if the difference persisted when
treatment changed to once daily.
METHODSIOP was
followed in 28 healthy volunteers in a double masked randomised 52 day
study. Latanoprost 50 µg/ml was administered once daily in one eye
and four times daily in the other during 2 weeks. Subsequently both
eyes received one daily drop for 2 weeks. After another 3 weeks without
treatment, a single drop was instilled in each eye.
RESULTSThe IOP
reduction on days 2 and 3 was greater in the eyes treated with four
daily doses (p<0.01). During the following period there were no
statistically significant differences between the eyes. After 3 weeks
without treatment the IOP was lower than pretreatment (p<0.001). A
single dose of latanoprost on day 50 resulted in a similar decrease in
IOP in both eyes. Transient photophobia, mild flare, and/or a few cells
occurred in 15 subjects. Two subjects were withdrawn because of
photophobia and/or signs of anterior uveitis.
CONCLUSIONLatanoprost
four times daily caused an IOP reducing effect which was similar to
once daily dosing, except for the first 2 days of treatment when it was
more effective. Transient photophobia, cells, and flare were common
during the four dose regimen, but resolved spontaneously without
cessation of treatment.
© 2001 by British Journal of Ophthalmology
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