Scientific correspondence
Plasma malondialdehyde and nitric oxide levels in age related
macular degeneration
Yüksel Totana, Osman Çekiça, Mehmet Borazana, Efkan Uzb, Sad
k Sö
a Department of
Ophthalmology, Turgut Özal Medical Centre, 
Correspondence to: Dr Yüksel Totan, Hastane caddesi No 44/7, 44300 Malatya, Turkey ytotan{at}usa.net
Accepted for publication 15 June 2001
AIMS
To evaluate
alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels
in patients with exudative age related macular degeneration (ARMD).
METHODSPlasma nitrite
plus nitrate concentrations as an index of plasma NO levels and plasma
MDA level as a marker of lipid peroxidation were measured in patients
with exudative ARMD and age and sex matched healthy subjects.
RESULTSSignificantly
higher MDA and lower NO levels were detected in plasma of patients with
ARMD compared with their controls (p=0.01, p=0.001, respectively).
CONCLUSIONThe results
may support involvement of oxidative damage and vascular theory in the
pathogenesis of ARMD as part of the ageing process.
© 2001 by British Journal of Ophthalmology
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