Scanning laser ophthalmoscopy of the optic nerve head in exfoliation glaucoma and ocular hypertension with exfoliation syndrome
Mika Harju, Eija Vesti
Helsinki University
Eye Hospital, PO Box 220, FIN-00029 HYKS, Finland
Correspondence to: Dr Mika Harju mika.harju{at}hueh.fi
Accepted for publication 4 October 2000
AIMS
To study the
relation between optic nerve head topography (Heidelberg retina
tomograph, HRT) and disc area, visual field index mean defect (MD), and
intraocular pressure (IOP), and to see whether change in HRT parameters
is associated with change in MD in a prospective follow up.
METHODS80 consecutive
patients (69 patients with exfoliation glaucoma and 11 with ocular
hypertension combined with exfoliation syndrome) were examined before
IOP reducing intervention and prospectively followed every 6 months for
2 years.
RESULTSAt the entry
point, multiple regression analysis showed significant linear
association between MD and all HRT parameters, when controlling for
disc area. Disc area showed significant association with cup area,
cup/disc area ratio, rim area, cup volume, and mean RNFL thickness. Six
months after intervention IOP had decreased significantly. Reversible
changes in cup area, cup/disc area ratio, rim area, cup volume, rim
volume, mean cup depth, and maximum cup depth were associated with
decrease in IOP. During the follow up period from 6 month to 2 years,
IOP did not change significantly, and MD was used as a measure of
progression of glaucoma. During this period, only cup shape measure
among HRT parameters showed significant association with subsequent
change in MD.
CONCLUSIONDisc area
should be taken into account when using HRT to compare patients. Any
effect of change in IOP should be also taken into account when using
HRT in follow up. Cup shape measure is a promising indicator of
progression of glaucomatous damage.
© 2001 by British Journal of Ophthalmology
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This article has been cited by other articles:
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Harju, M, Saari, J, Kurvinen, L, Vesti, E
(2008). Reversal of optic disc cupping in glaucoma. Br. J. Ophthalmol.
92: 901-905
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