© 2003 BMJ Publishing Group Ltd
EXTENDED REPORT
Intraocular pressure after replacement of current dual therapy with latanoprost monotherapy in patients with open angle glaucoma
1 Department of Ophthalmology, Augenklinik der Techn, Universität Dresden, Germany
2 Department of Ophthalmology, Uppsala University Hospital, Uppsala, Sweden
Correspondence to:
Correspondence to:
Professor Lutz Pillunat
Universitäts Augenklinik, Fetscherstrasse, D-01307 Dresden, Germany; direction{at}uniklinikum-dresden.de
Aims: To evaluate the efficacy and safety of replacing current dual ocular hypotensive therapy with latanoprost 0.005% monotherapy in patients with open angle glaucoma.
Methods: This randomised, open label, parallel group, multinational study included 466 patients with open angle glaucoma currently on dual ocular hypotensive therapy, including a ß adrenergic receptor antagonist. Patients were assigned (1:3) to ongoing dual therapy or a switch to monotherapy with latanoprost 0.005% once daily for 6 months. Intraocular pressure (IOP) was measured at 10 am and 5 pm at baseline, month 3, and month 6. Groups were compared for differences in diurnal IOP change, IOP success rates (IOP 
22 mm Hg with 15% increase from baseline), and clinical success rates (not requiring change in therapy).
Results: Baseline mean diurnal IOP was 17.8 (SD 2.0) mm Hg in the latanoprost group and 17.6 (2.1) mm Hg in the dual therapy group. After 6 months, mean diurnal IOP was reduced by 0.26 (0.18) (SEM 1.4%) mm Hg (p = 0.153) in the group switched to latanoprost and by 0.37 (0.25) (2.1%) mm Hg (p = 0.138) in those continuing dual therapy (difference: 0.11 mm Hg; p = 0.641). Success rates defined by IOP criteria were 83% for latanoprost and 89% for continued dual therapy (difference: 6%; p = 0.122). Clinical success rates were 97% for latanoprost and 99% for dual therapy (difference: 2%; p = 0.161). Ocular adverse events were reported by 23% of patients in both treatment groups.
Conclusion: Latanoprost monotherapy is a safe and effective alternative for many patients with open angle glaucoma requiring dual topical ocular hypotensive therapy for IOP control.
Keywords: intraocular pressure; latanoprost; open angle gluacoma
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