EXTENDED REPORT

A multicentre report from the Mexican Retinoblastoma Group

C Leal-Leal¹, M Flores-Rojo¹, A Medina-Sansón², F Cerecedo-Díaz³, S Sánchez-Félix⁴, O González-Ramella⁵, F Pérez-Pérez⁶, R Gómez-Martínez⁷, A Quero-Hernández⁸, E Altamirano-Álvarez⁹, F Alejo-González¹⁰, J Figueroa-Carbajal¹¹, A Ellis-Irigoyen¹², I Tejocote-Romero¹³, R Cervantes-Paz¹³, F Pantoja-Guillén¹⁴, L Vega-Vega¹⁵ and F Carrete-Ramírez¹⁶

¹ Instituto Nacional de Pediatría, DF, Mexico
² Hospital Infantil de México Federico Gómez, DF, Mexico
³ Centro Médico Nacional SXXI, DF, Mexico
⁴ Centro Médico La Raza, DF, Mexico
⁵ Hospital Civil de Guadalajara, Jalisco, Mexico
⁶ Hospital General de México, DF, Mexico
⁷ Centro Médico de Occidente IMSS, Jalisco, Mexico
⁸ Hospital del Niño Oaxaqueño, Oaxaca, Mexico
⁹ Hospital Pediátrico de Sinaloa, Sinaloa, Mexico
¹⁰ Hospital Central de San Luis Potosí, San Luis Potosí, Mexico
¹¹ Hospital del Niño Morelense, Morelos, Mexico
¹² Hospital del Niño de Villahermosa, Tabasco, Mexico
¹³ Instituto Materno Infantil de Estado de México, Mexico
¹⁴ Hospital O’Horan de Mérida, Yucatan, Mexico
¹⁵ Centro Estatal de Cancerología de Jalapa, Veracruz, Mexico
¹⁶ Hospital General de Durango, Durango, Mexico

Correspondence to:
Correspondence to:
Dr C Leal-Leal
Insurgentes Sur 3700-c Mexico 04530 Mexico City, Mexico; drcarlosaleal{at}msn.com

Background: Retinoblastoma (RB) is a relatively uncommon tumour in childhood. The incidence of retinoblastoma in Mexico is probably higher than the incidence reported worldwide, however there is not enough information about the characteristics of this illness in Mexico. This report aims to present the results of a multicentre clinical survey of RB in Mexico.

Methods: A retrospective study was carried out on all RB cases treated in 16 institutions during the last six years. The variables analysed were age at diagnosis, sex, affected eyes, treatment modalities, and pathological staging. Overall survival was obtained.

Results: The authors analysed 500 cases; age range was 0–182 months. There were 364 unilateral cases (72.8%). Enucleation was performed in 84.9% of the patients. The St Jude’s staging was: 7.4% stage I, 52.8% stage II, 18.0% stage III, 11.4% stage IV, 7.2% not evaluated, and 3.2% missing data. Chemotherapy was used in 74.4% of the patients. Disease free survival was 89% at 73 months follow up.

Conclusions: The paper presents a great number of cases and pioneers multicentre studies in paediatric ophthalmology and oncology in this country. Given the great number of patients in advanced stages and the variability on treatment schemes, it is evident that it is mandatory to work in a cooperative group and develop a national early detection programme as well as a treatment protocol which include all specialists involved in the care of patients with RB.

Abbreviations: RB, retinoblastoma

Keywords: retinoblastoma; multicentre; Mexico

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