SCIENTIFIC REPORT

Intraocular pressure variability in patients who reached target intraocular pressure

F K Malerbi, M Hatanaka, R M Vessani and R Susanna, Jr

Glaucoma Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil

Correspondence to:
Correspondence to:
Fernando Korn Malerbi
Glaucoma Department, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, Rua Capote Valente 171 Ap 122, São Paulo, SP, Brazil, 05409-000; marcelohatanaka{at}uol.com.br

Aim: To assess the intraocular pressure (IOP) variability in patients with primary open angle glaucoma (POAG) under clinical treatment who reached an established target pressure based on isolated office readings.

Methods: Retrospective analysis of 65 eyes from 65 POAG patients under clinical therapy who submitted to modified diurnal tension curve (mDTC) (measurements at every 3 hours between 8 am and 5 pm) followed by a water drinking test (WDT). All subjects had established target IOP 15 mm Hg at 11 am or 2 pm. IOP variability during mDTC or WDT was evaluated.

Results: mDTC revealed IOP measurements 17 mm Hg in 16 of 65 eyes (24.6%). Nine eyes (13.8%) presented values 18 mm Hg. The highest IOP detected by mDTC was 20 mm Hg in one patient (1.5%). WDT demonstrated IOP values 17 mm Hg in 32 of 65 eyes (49.2%). 22 eyes (33.8%) presented values 18 mm Hg after water ingestion. Moreover, IOP levels 20 mm Hg were observed in 14 eyes (21.5%).

Conclusion: A great percentage of POAG patients undergoing clinical treatment and with IOP control based on single office measurement present significantly higher IOP measurements when performing mDTC and, especially, the WDT.

Abbreviations: mDTC, modified diurnal tension curve; POAG, primary open angle glaucoma; WDT, water drinking test

Keywords: glaucoma; intraocular pressure

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• Susanna, R. Jr, Hatanaka, M., Vessani, R. M., Pinheiro, A., Morita, C. (2006). Correlation of Asymmetric Glaucomatous Visual Field Damage and Water-Drinking Test Response. IOVS 47: 641-644 [Abstract] [Full Text]