British Journal of Ophthalmology 2006;90:1370-1373
EXTENDED REPORT
Intraocular pressure-lowering efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Correspondence to:
Correspondence to:
L B Cantor
Department of Ophthalmology, Indiana University Medical Center, 702 Rotary Circle, Indianapolis, IN 46202, USA;lcantor{at}iupui.edu
Aim: To evaluate the efficacies of bimatoprost and travoprost for lowering of intraocular pressure (IOP) for the treatment of glaucoma and ocular hypertension.
Methods: Prospective, randomised, investigator-blinded, parallel-group clinical trial. After completing a washout of all glaucoma drugs, patients (n = 157) were randomised to bimatoprost or travoprost for 6 months. Visits were at baseline, 1 week, and 1, 3 and 6 months. IOP was measured at 09:00 h at each visit and also at 13:00 and 16:00 h at baseline and at 3 and 6 months.
Results: No significant between-group differences were observed in IOP at baseline, at 09:00, 13:00 or 16:00 h (p
0.741). After 6 months, both drugs significantly reduced IOP at every time point (p
0.001). After 6 months, mean IOP reduction at 09:00 h was 7.1 mm Hg (27.9%) with bimatoprost (n = 76) and 5.7 mm Hg (23.3%) with travoprost (n = 81; p = 0.014). At 13:00 h, mean IOP reduction was 5.9 mm Hg with bimatoprost (25.3%) and 5.2 mm Hg (22.4%) with travoprost (p = 0.213). At 16:00 h, the mean IOP reduction was 5.3 mm Hg (22.5%) with bimatoprost and 4.5 mm Hg (18.9%; p = 0.207) with travoprost. Both study drugs were well tolerated, with ocular redness the most commonly reported adverse event in both treatment groups.
Conclusions: Bimatoprost provided greater mean IOP reductions than travoprost.
Abbreviations: IOP, intraocular pressure; OAG, open-angle glaucoma; OHT, ocular hypertension
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Br. J. Ophthalmol. 2006 90: 1336-1337.
This article has been cited by other articles:
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Cantor, L B
(2008). Author's reply. Br. J. Ophthalmol.
92: 863-864
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