British Journal of Ophthalmology 2006;90:262-267; doi:10.1136/bjo.2005.081224
Copyright © 2006 by the BMJ Publishing Group Ltd.
The number of people with glaucoma worldwide in 2010 and 2020
H A Quigley,
A T Broman
The Glaucoma Service and the Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Baltimore, MD, USA
Correspondence to: Correspondence to: Harry Quigley Wilmer 122, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA; hquigley{at}jhmi.edu
ABSTRACT
Aim: To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020.
Methods: A review of published data with use of prevalence models. Data from population based studies of age specific prevalence of OAG and ACG that satisfied standard definitions were used to construct prevalence models for OAG and ACG by age, sex, and ethnicity, weighting data proportional to sample size of each study. Models were combined with UN world population projections for 2010 and 2020 to derive the estimated number with glaucoma.
Results: There will be 60.5 million people with OAG and ACG in 2010, increasing to 79.6 million by 2020, and of these, 74% will have OAG. Women will comprise 55% of OAG, 70% of ACG, and 59% of all glaucoma in 2010. Asians will represent 47% of those with glaucoma and 87% of those with ACG. Bilateral blindness will be present in 4.5 million people with OAG and 3.9 million people with ACG in 2010, rising to 5.9 and 5.3 million people in 2020, respectively.
Conclusions: Glaucoma is the second leading cause of blindness worldwide, disproportionately affecting women and Asians.
Keywords: glaucoma; prevalence; open angle; angle closure
Relevant Articles
-
Worldwide glaucoma through the looking glass
- R R A Bourne
Br. J. Ophthalmol. 2006 90: 253-254.
[Extract]
[Full Text]
[PDF]
-
BJO at a glance
- Creig Hoyt
Br. J. Ophthalmol. 2006 90: 253.
[Extract]
[Full Text]
[PDF]
This article has been cited by other articles:

|
 |

|
 |
 
Y. Zheng, J. Ge, G. Huang, J. Zhang, B. Liu, Y.-M. Hur, and M. He
Heritability of Central Corneal Thickness in Chinese: The Guangzhou Twin Eye Study
Invest. Ophthalmol. Vis. Sci.,
October 1, 2008;
49(10):
4303 - 4307.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Shibuya, A. Meguro, M. Ota, K. Kashiwagi, F. Mabuchi, H. Iijima, K. Kawase, T. Yamamoto, M. Nakamura, A. Negi, et al.
Association of Toll-like Receptor 4 Gene Polymorphisms with Normal Tension Glaucoma
Invest. Ophthalmol. Vis. Sci.,
October 1, 2008;
49(10):
4453 - 4457.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Y. Shen, T. Y. Wong, P. J. Foster, J.-L. Loo, M. Rosman, S.-C. Loon, W. L. Wong, S.-M. Saw, and T. Aung
The Prevalence and Types of Glaucoma in Malay People: The Singapore Malay Eye Study
Invest. Ophthalmol. Vis. Sci.,
September 1, 2008;
49(9):
3846 - 3851.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. D. Bull, G. A. Limb, and K. R. Martin
Human Muller Stem Cell (MIO-M1) Transplantation in a Rat Model of Glaucoma: Survival, Differentiation, and Integration
Invest. Ophthalmol. Vis. Sci.,
August 1, 2008;
49(8):
3449 - 3456.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Chakrabarti, K. N. Rao, I. Kaur, R. S. Parikh, A. K. Mandal, G. Chandrasekhar, and R. Thomas
The LOXL1 Gene Variations Are Not Associated with Primary Open-Angle and Primary Angle-Closure Glaucomas
Invest. Ophthalmol. Vis. Sci.,
June 1, 2008;
49(6):
2343 - 2347.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Fernandez-Durango, A. Fernandez-Martinez, J. Garcia-Feijoo, A. Castillo, J. M. de la Casa, B. Garcia-Bueno, B. G. Perez-Nievas, A. Fernandez-Cruz, and J. C. Leza
Expression of Nitrotyrosine and Oxidative Consequences in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma
Invest. Ophthalmol. Vis. Sci.,
June 1, 2008;
49(6):
2506 - 2511.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Asrani, M. Sarunic, C. Santiago, and J. Izatt
Detailed Visualization of the Anterior Segment Using Fourier-Domain Optical Coherence Tomography
Arch Ophthalmol,
June 1, 2008;
126(6):
765 - 771.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Zhou, O. Grinchuk, and S. I. Tomarev
Transgenic Mice Expressing the Tyr437His Mutant of Human Myocilin Protein Develop Glaucoma
Invest. Ophthalmol. Vis. Sci.,
May 1, 2008;
49(5):
1932 - 1939.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W.-H. Wang, L. G. McNatt, I.-H. Pang, P. E. Hellberg, J. H. Fingert, M. D. McCartney, and A. F. Clark
Increased Expression of Serum Amyloid A in Glaucoma and Its Effect on Intraocular Pressure
Invest. Ophthalmol. Vis. Sci.,
May 1, 2008;
49(5):
1916 - 1923.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. S. Juzych, S. Randhawa, A. Shukairy, P. Kaushal, A. Gupta, and N. Shalauta
Functional Health Literacy in Patients With Glaucoma in Urban Settings
Arch Ophthalmol,
May 1, 2008;
126(5):
718 - 724.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Weng, J. Luo, X. Cheng, C. Jin, X. Zhou, J. Qu, L. Tu, D. Ai, D. Li, J. Wang, et al.
Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2
PNAS,
April 22, 2008;
105(16):
6081 - 6086.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. P. Buckingham, D. M. Inman, W. Lambert, E. Oglesby, D. J. Calkins, M. R. Steele, M. L. Vetter, N. Marsh-Armstrong, and P. J. Horner
Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma
J. Neurosci.,
March 12, 2008;
28(11):
2735 - 2744.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S Shukla, K F Damji, P Harasymowycz, D Chialant, J S Kent, R Chevrier, R Buhrmann, D Marshall, Y Pan, and W Hodge
Clinical features distinguishing angle closure from pseudoplateau versus plateau iris
Br. J. Ophthalmol.,
March 1, 2008;
92(3):
340 - 344.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. B. Berry, J. M. Skarie, F. Mirzayans, Y. Fortin, T. J. Hudson, V. Raymond, B. A. Link, and M. A. Walter
FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A
Hum. Mol. Genet.,
February 14, 2008;
17(4):
490 - 505.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
I. Soto, E. Oglesby, B. P. Buckingham, J. L. Son, E. D. O. Roberson, M. R. Steele, D. M. Inman, M. L. Vetter, P. J. Horner, and N. Marsh-Armstrong
Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model
J. Neurosci.,
January 9, 2008;
28(2):
548 - 561.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. T. Broman, H. A. Quigley, S. K. West, J. Katz, B. Munoz, K. Bandeen-Roche, J. M. Tielsch, D. S. Friedman, J. Crowston, H. R. Taylor, et al.
Estimating the Rate of Progressive Visual Field Damage in Those with Open-Angle Glaucoma, from Cross-Sectional Data
Invest. Ophthalmol. Vis. Sci.,
January 1, 2008;
49(1):
66 - 76.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. W. Rozsa, K. Scott, H. Pawar, S. Moroi, and J. E. Richards
Effects of Timolol on MYOC, OPTN, and WDR36 RNA Levels
Arch Ophthalmol,
January 1, 2008;
126(1):
86 - 93.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J L Y Yip, P J Foster, C E Gilbert, D Uranchimeg, J Bassanhuu, P S Lee, P T Khaw, G J Johnson, and W Nolan
Incidence of occludable angles in a high-risk Mongolian population
Br. J. Ophthalmol.,
January 1, 2008;
92(1):
30 - 33.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. K. Abu-Amero, J. Morales, M. N. Osman, and T. M. Bosley
Nuclear and Mitochondrial Analysis of Patients with Primary Angle-Closure Glaucoma
Invest. Ophthalmol. Vis. Sci.,
December 1, 2007;
48(12):
5591 - 5596.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Sakata, L. M. Sakata, V. M. Sakata, C. Santini, L. M. Hopker, R. Bernardes, C. Yabumoto, and A. T. R. Moreira
Prevalence of Glaucoma in a South Brazilian Population: Projeto Glaucoma
Invest. Ophthalmol. Vis. Sci.,
November 1, 2007;
48(11):
4974 - 4979.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Saleh, M. Nagaraju, and V. Porciatti
Longitudinal Evaluation of Retinal Ganglion Cell Function and IOP in the DBA/2J Mouse Model of Glaucoma
Invest. Ophthalmol. Vis. Sci.,
October 1, 2007;
48(10):
4564 - 4572.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Guo, T. E. Salt, V. Luong, N. Wood, W. Cheung, A. Maass, G. Ferrari, F. Russo-Marie, A. M. Sillito, M. E. Cheetham, et al.
Targeting amyloid-beta in glaucoma treatment
PNAS,
August 14, 2007;
104(33):
13444 - 13449.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. M. E. van Koolwijk, D. D. G. Despriet, C. M. van Duijn, L. M. Pardo Cortes, J. R. Vingerling, Y. S. Aulchenko, B. A. Oostra, C. C. W. Klaver, and H. G. Lemij
Genetic Contributions to Glaucoma: Heritability of Intraocular Pressure, Retinal Nerve Fiber Layer Thickness, and Optic Disc Morphology
Invest. Ophthalmol. Vis. Sci.,
August 1, 2007;
48(8):
3669 - 3676.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Y C Lee, F. Rensch, T. Aung, L. S Lim, R. Husain, G. Gazzard, S. K L Seah, and J. B Jonas
Peripapillary atrophy after acute primary angle closure
Br. J. Ophthalmol.,
August 1, 2007;
91(8):
1059 - 1061.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. C. Johnson, L. Jia, W. O. Cepurna, T. A. Doser, and J. C. Morrison
Global Changes in Optic Nerve Head Gene Expression after Exposure to Elevated Intraocular Pressure in a Rat Glaucoma Model
Invest. Ophthalmol. Vis. Sci.,
July 1, 2007;
48(7):
3161 - 3177.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. P Nolan
Prevention of primary angle-closure glaucoma in Asia
Br. J. Ophthalmol.,
July 1, 2007;
91(7):
847 - 848.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R J Casson, H S Newland, J Muecke, S McGovern, L M Abraham, W K Shein, D Selva, and T Aung
Gonioscopy findings and prevalence of occludable angles in a Burmese population: the Meiktila Eye Study
Br. J. Ophthalmol.,
July 1, 2007;
91(7):
856 - 859.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R J Casson, H S Newland, J Muecke, S McGovern, L Abraham, W K Shein, D Selva, and T Aung
Prevalence of glaucoma in rural Myanmar: the Meiktila Eye Study
Br. J. Ophthalmol.,
June 1, 2007;
91(6):
710 - 714.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. R. Pasquale
Genes Involved in the Pathogenesis of Primary Open-Angle Glaucoma: In Search of the Holy Grail
JAMA,
January 17, 2007;
297(3):
306 - 307.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. W. Hewitt, S. L. Bennett, J. H. Fingert, R. L. Cooper, E. M. Stone, J. E. Craig, and D. A. Mackey
The Optic Nerve Head in Myocilin Glaucoma
Invest. Ophthalmol. Vis. Sci.,
January 1, 2007;
48(1):
238 - 243.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. McLaren, D. M. Reed, D. C. Musch, C. A. Downs, M. E. Higashi, C. Santiago, P. A. Radenbaugh, R. R. Allingham, J. E. Richards, and S. E. Moroi
Evaluation of the beta2-Adrenergic Receptor Gene as a Candidate Glaucoma Gene in 2 Ancestral Populations
Arch Ophthalmol,
January 1, 2007;
125(1):
105 - 111.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A T Fung, S E Reid, M P Jones, P R Healey, P J McCluskey, and J C Craig
Meta-analysis of randomised controlled trials comparing latanoprost with brimonidine in the treatment of open-angle glaucoma, ocular hypertension or normal-tension glaucoma
Br. J. Ophthalmol.,
January 1, 2007;
91(1):
62 - 68.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Funayama, Y. Mashima, Y. Ohtake, K. Ishikawa, N. Fuse, N. Yasuda, T. Fukuchi, A. Murakami, Y. Hotta, N. Shimada, et al.
SNPs and Interaction Analyses of Noelin 2, Myocilin, and Optineurin Genes in Japanese Patients with Open-Angle Glaucoma
Invest. Ophthalmol. Vis. Sci.,
December 1, 2006;
47(12):
5368 - 5375.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. He, P. J. Foster, J. Ge, W. Huang, D. Wang, D. S. Friedman, and P. T. Khaw
Gonioscopy in Adult Chinese: The Liwan Eye Study
Invest. Ophthalmol. Vis. Sci.,
November 1, 2006;
47(11):
4772 - 4779.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J E Craig, A W Hewitt, D P Dimasi, N Howell, C Toomes, A C Cohn, and D A Mackey
The role of the Met98Lys optineurin variant in inherited optic nerve diseases
Br. J. Ophthalmol.,
November 1, 2006;
90(11):
1420 - 1424.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C E D van Isterdael, J S Stilma, P D Bezemer, and N T Tijmes
6220 institutionalised people with intellectual disability referred for visual assessment between 1993 and 2003: overview and trends
Br. J. Ophthalmol.,
October 1, 2006;
90(10):
1297 - 1303.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. K. P. Sullivan, E. WoldeMussie, L. Macnab, G. Ruiz, and D. V. Pow
Evoked Expression of the Glutamate Transporter GLT-1c in Retinal Ganglion Cells in Human Glaucoma and in a Rat Model.
Invest. Ophthalmol. Vis. Sci.,
September 1, 2006;
47(9):
3853 - 3859.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. A. Quigley
Chase the Family
Arch Ophthalmol,
July 1, 2006;
124(7):
1036 - 1037.
[Full Text]
[PDF]
|
 |
|
|
|