British Journal of Ophthalmology 2006;90:555-558
SCIENTIFIC REPORT
Optical coherence tomography to monitor photodynamic therapy in pathological myopia
Department of Ophthalmology, University Clinic, University of Navarra, Pamplona, Spain
Correspondence to:
Correspondence to:
Alfredo García-Layana
Department of Ophthalmology, Clínica Universitaria de Navarra, Avda Pío XII, 36, 31080 Pamplona, Spain; aglayana{at}unav.es
Aim: To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularisation (CNV) activity before and after photodynamic therapy (PDT) in patients with pathological myopia.
Methods: 33 patients (33 eyes) with pathological myopia and being treated with PDT were included. Every 3 months all patients were evaluated and presence or absence of leakage on fluorescein angiography, presence of intraretinal or subretinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT, were determined at each examination.
Results: The macular thickness decreased significantly after PDT at 6 months (p = 0.001) and at 12 months follow up (p = 0.01). However, no significant changes in CNV thickness were measured after PDT at 6 months of follow up (p = 0.418) and at 12 months of follow up (p = 0.521). Once the diagnosis of CNV associated with pathological myopia was established, before treatment, OCT had a sensitivity of 96.96% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.23%) and a moderate specificity (69,69%) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 79.62%.
Conclusions: OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with pathological myopia.
Abbreviations: AMD, age related macular degeneration; BCVA, best corrected visual acuity; CNV, choroidal neovascularisation; FA, fluorescein angiography; OCT, optical coherence tomography; PDT, photodynamic therapy; RPE, retinal pigment epithelium; VIP study, Verteporfin in Photodynamic study
Keywords: photodynamic therapy; myopia; choroidal neovacularisation; optical coherence tomography; fluorescein angiography
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