SCIENTIFIC REPORT

Does use of isotretinoin rule out a career in flying?

S P Mollan¹, M Woodcock^1,2, R Siddiqi¹, J Huntbach^2,3, P Good¹ and R A H Scott^1,2

¹ Birmingham and Midland Eye Centre, City Hospital, Birmingham, UK
² Royal Centre of Defence Medicine, Birmingham, UK
³ Queen’s Medical Centre, Nottingham, UK

Correspondence to:
Correspondence to:
MissSusan P Mollan
Birmingham and Midland Eye Centre, City Hospital, Dudley Road, Birmingham B18 7QH, UK; soozmollan{at}doctors.org.uk

Aim: To evaluate whether previous isotretinoin use induces permanent, measurable, and clinically significant abnormalities in night vision such that flying is precluded, and whether potential military and civilian commercial aviators should be screened routinely.

Methods: A retrospective, non-interventional, consecutive case series of 47 individuals with a confirmed history of oral isotretinoin use were compared to 20 age and sex matched controls.

Results: 47 individuals (44 males and three females), age range 17–33, underwent Goldmann-Weekers dark adaptation (DA) and standard electroretinogram (ERG) according to ISCEV protocols. 34 patients showed no abnormality in any parameters. Two patients had abnormal DA and ERGs. The mean scotopic ERG b wave amplitude of the isotretinoin group was 496.5 µV (SD 51.3 µV) compared with 501.7 µV (62.3.1 µV) among the controls. The group mean a:b ratio was 0.55 (0.04) compared to 0.69 (0.08) in the controls.

Conclusion: Previous use of isotretinoin may have caused retinal toxicity in two subjects and laboratory evidence of night blindness in 11 further subjects. One subject had subclinical changes remaining in the ERG 96 months after cessation of isotretinoin. This may justify the directed use of electrophysiological screening in professions that are night vision critical.

Abbreviations: DA, dark adaptation; ERG, electroretinogram; ISCEV, International Society for Clinical Electrophysiology of Vision; RPE, retinal pigment epithelium; SF, standard flash

Keywords: dark adaptation; electrodiagnostic testing; isotretinoin

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

BJO at a glance

Creig Hoyt
Br. J. Ophthalmol. 2006 90: 931. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Pushpoth, S, Sandramouli, S (2007). Isotretinoin and night vision. Br. J. Ophthalmol. 91: 1096-1096 [Full Text]  
• Mollan, S. P, Woodcock, M., Good, P., Scott, R. A H (2007). Isotretinoin and night vision: authors' response. Br. J. Ophthalmol. 91: 1096-1096 [Full Text]