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British Journal of Ophthalmology 2007;91:585-587; doi:10.1136/bjo.2006.0107276 Copyright © 2007 by the BMJ Publishing Group Ltd.
Risk of non-arteritic anterior ischaemic optic neuropathy (NAION) after cataract extraction in the fellow eye of patients with prior unilateral NAIONByron L Lam1, Haneen Jabaly-Habib1, Nabih Al-Sheikh1, Matthew Pezda1, Medhat F Guirgis1, William J Feuer1, Timothy J McCulley2
1 University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA
Correspondence to:
Design: Retrospective, cohort study. Methods: Medical records of patients with NAION evaluated in our institution between 1 January 1986 and 31 December 2001 were reviewed to determine the onset of NAION and the time of CE. Patients were excluded if the date of NAION and CE was unreliable, or if CE in the fellow eye was performed before the unilateral NAION. Statistical analysis was performed by including fellow eye CE as a time-dependent covariate in a Cox proportional hazards regression model of NAION incidence in the fellow eye. Results: Of the 325 eligible patients, 9 (53%) of 17 patients with NAION who underwent CE in the fellow eye developed fellow eye NAION, and 59 (19%) of 308 patients with NAION who did not undergo CE in the fellow eye developed fellow eye NAION. Cataract extraction in the fellow eye increased the risk of NAION occurrence in the fellow eye by 3.6-fold (Cox regression, p = 0.001). Conclusions: Patients with unilateral NAION are at a significantly higher risk of developing NAION in the fellow eye after CE.
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