SCIENTIFIC REPORT

Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis

Yumiko Yoshida¹, Sho-ichi Yamagishi², Takanori Matsui², Kazuo Nakamura², Tsutomu Imaizumi², Koichi Yoshimura¹ and Ryoji Yamakawa¹

¹ Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan
² Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan

Correspondence to:
Correspondence to:
Dr S Yamagishi
Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan; shoichi{at}med.kurume-u.ac.jp

Aim: To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.

Methods: Aqueous humour levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.

Results: Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) µg/ml vs 5.01 (0.92) µg/ml vs 1.32 (0.22) µg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01).

Conclusion: The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis.

Abbreviations: MCP-1, monocyte chemoattractant protein-1; PEDF, pigment epithelium-derived factor

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