ORIGINAL ARTICLES
The association between conjunctival MALT lymphoma and Helicobacter pylori
1 Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea
2 Research Institute for Medical Science, Chungnam National University, Daejeon, Republic of Korea
3 Cancer Research Institute, Chungnam National University Hospital, Daejeon, Republic of Korea
4 Department of Ophthalmology, Inje University College of Medicine, Busan, Republic of Korea
Correspondence to:
Chang-Sik Kim, Department of Ophthalmology, Chungnam National University Hospital, #640 Daesa-dong, Jung-gu, Daejeon 301-721, Korea; kcs61{at}cnu.ac.kr
Background/aims: Helicobacter pylori is well known to be responsible for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. This study evaluates whether H pylori is also responsible for conjunctival MALT lymphoma and which strain of H pylori is associated with conjunctival MALT lymphoma.
Methods: Fifteen cases of conjunctival MALT lymphoma were investigated. Eight biopsies of normal conjunctiva were also investigated as controls. The specimens were investigated for the presence of H pylori DNA with polymerase chain reaction (PCR) using 16S rDNA primer. When the PCR using 16S rDNA was positive for H pylori, the specimens were analysed for the virulent gene with PCR using vacA s1/2 primer and vacA m1/2 primer.
Results: H pylori DNA was identified in all 15 specimens of conjunctival MALT lymphomas and none of the controls. Of these 15 H pylori positive lymphoma specimens, the vacA s1 and vacA m2 alleles were detected in two, and only vacA s1 allele was detected in 11.
Conclusions: H pylori is thought to play a role in the pathogenesis of conjunctival MALT lymphoma, and H pylori with vacA s1 allele appears to be a virulent strain for conjunctival MALT lymphoma.
Competing interests: None.
Ethics approval: This study was approved by the institutional research board of Chungnam National University Hospital and Inje University Busan Paik Hospital.
Patient consent: All patients gave written informed consent after the aim of the study and operation had been fully explained.
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