ORIGINAL ARTICLES

Twenty-four-hour intraocular pressure and blood pressure levels with bimatoprost versus latanoprost in patients with normal-tension glaucoma

L Quaranta¹, T Pizzolante¹, I Riva¹, A-B Haidich², A G P Konstas³ and W C Stewart^4,5

¹ Department of Ophthalmology, University of Brescia, Brescia, Italy
² Department of Hygiene, Aristotle University of Thessaloniki, Thessaloniki, Greece
³ Glaucoma Unit, 1st University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
⁴ PRN Pharmaceutical Research Network, LLC, Dallas, Texas, USA
⁵ Carolina Eye Institute, University of South Carolina, Columbia, South Carolina, USA

Correspondence to:
Dr W C Stewart, 5001 LBJ Freeway, Suite 700, Dallas, TX 75244, USA; info{at}prnorb.com

Aim: To evaluate 24 h intraocular pressure (IOP) and blood pressure (BP) with bimatoprost or latanoprost in patients with normal-tension glaucoma.

Design: Prospective, randomised, crossover, active-controlled, observer-masked study.

Methods: After a 6-week medicine-free period, we randomised patients to either latanoprost or bimatoprost for 8 weeks and then to the opposite medicine for 8 weeks. At baseline, and at the end of each treatment period, we evaluated IOP and BP at 08:00 and then every 2 h over the 24 h day. Diastolic ocular perfusion pressure (DOPP) was calculated from the above parameters.

Results: Forty completed patients had a 24 h untreated baseline IOP of 15.5 (2.3) mm Hg, and a DOPP of 59.2 (6.1) mm Hg. Both treatments lowered IOP at each time point (p<0.006), and over the 24 h curve (p<0.001, both medicines 13.1 mm Hg, 16% decrease). No difference existed between treatments in absolute IOP, at each time point, and over the 24 h curve (p0.26). Additionally, no differences were found between treated 24 h systolic (p0.29) and diastolic BP (p0.12). The mean 24 h DOPP for latanoprost was increased from baseline (3%, p = 0.031) but not for bimatoprost (2%, p = 0.21). However, no difference in DOPP existed between treatments at any time point or over the 24 h curve (p0.17). No difference was observed between treatments for any adverse event (p>0.05).

Conclusions: In patients with normal-tension glaucoma, both bimatoprost and latanoprost reduce the 24 h intraocular pressure from untreated baseline to a similar extent. Latanoprost is associated with slightly improved ocular diastolic perfusion pressure over 24 h but similar absolute perfusion levels to that of bimatoprost.

Competing interests: None.

Ethics approval: Ethics approval was provided by Clinica Oculistica, The University of Brescia, Brescia, Italy.

Patient consent: Obtained.

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