Editorial
Ploidy analysis in uveal melanoma
| The first 150 words of the full text of this article appear below. |
For uveal melanoma it has been shown that nuclear DNA content (ploidy) abnormalities correlate closely with survival,1-4 although conflicting results have been reported for older archival material,5 fresh tissue,6 and differences in DNA quantification techniques.7 A significant correlation between aneuploidy and epithelioid cell type has been reported2 3 8; other studies indicate similar findings,9 or contradict these findings.4 In this issue of the BJO (p 1433) Toti et al report conflicting results on the prognostic value of aneuploidy and association of aneuploidy with epithelioid cell type in uveal melanoma. Furthermore, they found a remarkably high incidence of hypodiploidy.
Methods for ploidy analysis include flow cytometry (FCM), static image
analysis (IA), and
more recentlythe cytogenetic approach. Each
ploidy analysis has its own advantages and disadvantages, many of which
reflect the reported conflicting results.10 11 Ploidy
analysis by FCM and IA has been reported for uveal
melanoma.1-9 12 13 Both methods plot the cells
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- DNA ploidy pattern in choroidal melanoma: correlation with survival. A flow cytometry study on archival material
- Paolo Toti, Giuseppe Greco, Paola Mangiavacchi, Alessandra Bruni, Marie Louise Desirèe Palmeri, and Pietro Luzi
Br. J. Ophthalmol. 1998 82: 1433-1437.[Abstract] [Full Text] [PDF]
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