Editorial
Growth factors in proliferative vitreoretinopathy
| The first 150 words of the full text of this article appear below. |
Surgical repair of retinal detachment complicated by proliferative vitreoretinopathy (PVR) remains complex and time consuming. Visual results of such surgery are frequently disappointing. Dissecting the network of growth factors/cytokines involved in PVR is a comparable challenge which may eventually result in improved anatomical and visual outcomes.
Several lines of evidence point to a role for soluble mediators
("growth factors") in the process of periretinal membrane formation
seen in PVR. Firstly, studies of cellular healing responses in other
tissues have demonstrated a role for a number of growth factors
(sometimes termed "fibrogenic cytokines") in mediating cellular
chemotaxis and proliferation, neovascularisation, extracellular matrix
production, wound remodelling, and contraction, processes essential to
the normal wound healing response.1 2 Secondly, several
in vitro investigations have demonstrated that retinal pigment
epithelium and retinal glia are responsive to a number of growth
factors.3-6 The in vitro retinal pigment epithelium mediated contraction of collagen gels has also been
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders
- L Cassidy, P Barry, C Shaw, M J Duffy, and S Kennedy
Br. J. Ophthalmol. 1998 82: 181-185.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
-
Sethi, C. S., Lewis, G. P., Fisher, S. K., Leitner, W. P., Mann, D. L., Luthert, P. J., Charteris, D. G.
(2005). Glial Remodeling and Neural Plasticity in Human Retinal Detachment with Proliferative Vitreoretinopathy. IOVS
46: 329-342
[Abstract] [Full Text] -
Parapuram, S. K., Ganti, R., Hunt, R. C., Hunt, D. M.
(2003). Vitreous Induces Components of the Prostaglandin E2 Pathway in Human Retinal Pigment Epithelial Cells. IOVS
44: 1767-1774
[Abstract] [Full Text] -
Hogg, P. A., Grierson, I., Hiscott, P.
(2002). Direct Comparison of the Migration of Three Cell Types Involved in Epiretinal Membrane Formation. IOVS
43: 2749-2757
[Abstract] [Full Text] -
Haynes, R. J., McElveen, J. E., Dua, H. S., Tighe, P. J., Liversidge, J.
(2000). Expression of Human Beta-Defensins in Intraocular Tissues. IOVS
41: 3026-3031
[Abstract] [Full Text]
- Full Text
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
