Editorial
Serological tests for monitoring and predicting disease severity, course, and outcome of autoimmune intraocular inflammation
| The first 150 words of the full text of this article appear below. |
Around 50% of cases of uveitis are classified as idiopathic,
while many of the others are associated with or form part of other
disease entities.1 2 Idiopathic uveitis comprises a spectrum of CD4+ T cell mediated MHC class II restricted,
chronic autoimmune intraocular inflammatory conditions,3
the underlying immunological effector mechanisms of which have many
features in common with systemic conditions associated with intraocular
inflammation
for example, sarcoidosis, Behçet's disease,
seronegative spondyloarthropathies, and multiple
sclerosis.4 Therapy for these conditions must be tailored
to treat both ocular and systemic disease, although successful
immunosuppression for the ocular inflammatory component can be achieved
using the same approach as for idiopathic chronic intraocular
inflammation, especially if the systemic component is
inactive.5 Recognising whether intraocular inflammation is
idiopathic or associated with systemic disease either at the time of
presentation or in the future is difficult. For example, the term
"intermediate uveitis", which includes pars planitis, not only
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- Elevated serum IL-8 levels are associated with disease activity in idiopathic intermediate uveitis
- Anne-Marie Klok, Leny Luyendijk, Michel J W Zaal, Aniki Rothova, C Erik Hack, and Aize Kijlstra
Br. J. Ophthalmol. 1998 82: 871-874.[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text]
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