Editorial
Combination HIV therapy and opportunistic infections of the eye in people with AIDS
| The first 150 words of the full text of this article appear below. |
The past 2 years have seen a dramatic improvement in the
prognosis for people with HIV infection owing to the success of a strategy of using a combination of antiretroviral drugs to bring about
a profound and durable suppression of viral replication. The drugs
currently available all work through inhibiting key HIV specific
enzymes
reverse transcriptase and HIV protease. The use of a three
drug cocktail, usually consisting of two reverse transcriptase
inhibitors (RTI) and one protease inhibitor (PI), has shown itself to
be superior to single1 and dual2 3 drug
therapy in terms of the degree of viral suppression and also the
ability to stall the development of resistance.4-7
HIV damages the immune system primarily by promoting the destruction of
CD4 T lymphocytes, and this leaves the individual vulnerable to a
greater number of infections as the cell numbers decline. Following the
instigation of triple combination, highly active antiretroviral
therapy, often
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