Editorial
The healing optic nerve in glaucoma: transforming growth factor
and optic nerve head remodelling
| The first 150 words of the full text of this article appear below. |
Despite the many advances in the therapy and diagnosis of
primary open angle glaucoma, and the recognition of intraocular pressure as the major modifiable risk factor,1 2 the
pathogenesis of the disease still remains unclear. The most
pathognomonic feature of glaucoma is optic disc cupping and the primary
site of glaucomatous optic nerve damage appears to be at the optic
nerve head.3 However, the exact mechanisms by which this
damage occurs have not been elucidated. Changes in lamina cribrosa
morphology and nerve fibre bundle pore morphometry4 5
have been documented in this disease, in association with alterations
in the surrounding extracellular matrix.6-11 The tortuous
course of the individual nerve fibres may also play a
role.12 In this issue of the
BJO (p 209), Pena et
al have found that the production of a growth factor,
transforming growth factor 
(TGF-2) is considerably increased in
the optic nerve heads of patients with
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Transforming growth factor isoforms in human optic nerve heads
- Janethe D O Pena, Andrew W Taylor, Cynthia S Ricard, Ivonne Vidal, and M Rosario Hernandez
Br. J. Ophthalmol. 1999 83: 209-218.[Abstract] [Full Text] [PDF]
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