Editorial
Much more than water
| The first 150 words of the full text of this article appear below. |
The belief that the tear film is aqueous based and the ocular surface changes seen in Sjögren's syndrome are due to desiccation, cause eye care practitioners to water the dry eye. Studies show the tear film is dominated by mucin and not water.1 2 It is not a 7-10 µm thin film, but a 30-35 µm thick mucin gel. Bicarbonate may be critical to forming this gel as it is in forming the bicarbonate mucin gel that protects the stomach from autodigestion.3 The hallmark of the aqueous deficient dry eye, rose bengal staining of the conjunctiva, is not produced by desiccated cells, but is due to a deficiency in the protective mucin gel.4
The first major innovation in the treatment of the dry eye seen in
Sjögren's syndrome was the introduction of preservative-free artificial tears. Although the absence of preservatives allowed frequent topical application, the improvement seen in these severe dry
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Br. J. Ophthalmol. 1999 83: 390-395.[Abstract] [Full Text] [PDF]
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