Editorial
Anticipation for enzymatic vitreolysis
| The first 150 words of the full text of this article appear below. |
In this issue of the BJO (p
6), Gandorfer and colleagues contribute to the recent burgeoning of
research on enzymatic vitreolysis. Vitreoretinal surgeons, the
beneficiaries in recent years of many surgical advances
silicone oil
and long acting gas tamponade, perfluorocarbon liquids, photodynamic
therapynevertheless harbour a collective "wish list" of surgical
agents and devices awaiting development. Such a list would include
long term heavy liquid tamponade, retinal adhesives,
antifibroproliferative drugs, and antiangiogenic treatments. But
none figures so prominently as enzymatic vitreolysis, which for
years has held the promise of minimally invasive solutions for surgical
problems in vitreoretinal diseases such as diabetic retinopathy and
macular hole.
The goal is to develop chemicals which when injected into the vitreous
produce selective vitreolysis, in the form of either posterior vitreous
detachment (PVD) or vitreous liquefaction. Enzymatic vitreolysis is
envisaged to augment or even replace standard mechanical vitrectomy,
over which it presents important
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- Ultrastructure of the vitreoretinal interface following plasmin assisted vitrectomy
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[Abstract] [Full Text]
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