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Seasonal allergic conjunctivitis or hay fever conjunctivitis is a hypersensitivity reaction to specific airborne allergens, mainly pollens. It has a high prevalence rate and can be quite uncomfortable for the affected patient. A number of new topical treatments have been developed recently. Ketotifen blocks histamine H1 receptors, stabilises mass cells and prevents eosinophil accumulation. Kidd and coworkers report a double masked randomised multicentre trial conducted in Australia. In this study ketotifen 0.025% ophthalmic solution was well tolerated and effective in reducing the signs and symptoms of seasonal allergic conjunctivitis and in preventing recurrences. It consistently was most efficacious in comparison with a placebo and levocabastine. See p 1206
Successful restoration of vision with paediatric penetrating keratoplasty has only been achieved in the past two decades. In children the potential for post-surgical anterior segment inflammation that may accelerate graft rejection has been seen as a major obstacle for successful penetrating keratoplasty.
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