© 2003 BMJ Publishing Group Ltd
EDITORIAL
Corneal wounds
Corneal fibrotic wound repair
University of Florida Health Science Center, 1600 SW Archer Road, Gainsville, FL 32610–0294, USA; schultzg@obgyn.ufl.edu
It may be possible to regulate corneal scarring by controlling the activity of key genes
Keywords: corneal fibrotic wound repair
| The first 150 words of the full text of this article appear below. |
Corneal scarring following trauma, infections, or refractive surgery can produce blinding complications, but current treatment options are limited and outcomes are typically poor. Thus, there is a need for new treatments that will prevent or reduce corneal scarring with minimal side effects. To accomplish this, however, the basic processes that regulate corneal scarring need to be understood more thoroughly. Corneal wound healing is an exceedingly complex process that is coordinated and regulated in large part by autocrine and paracrine interactions of growth factors, cytokines, and proteases produced by epithelial cells, fibroblasts, and lacrimal gland cells. Also important are the interactions of corneal epithelial cells with components of the stromal extracellular matrix. Lacking from the understanding of corneal wound healing, however, has been a simultaneous spatial localisation of growth factors, corneal cells, and extracellular matrix proteins in healing corneal wounds. In this issue of the BJO (p 000)
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Characterisation of corneal fibrotic wound repair at the LASIK flap margin
- A Ivarsen, T Laurberg, and T Møller-Pedersen
Br. J. Ophthalmol. 2003 87: 1272-1278.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
-
Ramaesh, T., Ramaesh, K., Leask, R., Springbett, A., Riley, S. C., Dhillon, B., West, J. D.
(2006). Increased Apoptosis and Abnormal Wound-Healing Responses in the Heterozygous Pax6+/- Mouse Cornea. IOVS
47: 1911-1917
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
