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© 2004 BMJ Publishing Group Ltd
OverviewE ChewSeries editors: Susan Lightman and Peter McCluskey
Lead clinician, Building 31, Room 6A52, 31 Center Drive, MSC 2510, Bethesda, MD 20892-2510, USA; echew@nei.nih.gov
Keywords: diabetic retinopathy; macular oedema; vision loss; vitrectomy
This patient has both medical and ocular conditions that need to be addressed. It is important to emphasise the need to improve his glycaemic control. This information should be communicated to his primary care physician to initiate tighter control of his glycaemia. In the UK Prospective Diabetes Study (UKPDS), the largest and longest randomised study of intensive v conventional glucose control in patients with type 2 diabetes, there was a 25% reduction in the risk of the "any diabetes related microvascular end point," including the need for retinal photocoagulation in the intensive treatment group compared with the conventional treatment group.1 After 6 years of follow up, a smaller proportion of patients in the intensive treatment group than in the conventional group had a two step progression (worsening) in diabetic retinopathy (p<0.01). Epidemiological analysis of the UKPDS data showed a continuous relation between the risk of microvascular complications and glycaemia,
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