This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stewart, J M Search for Related Content PubMed PubMed Citation Articles by Stewart, J M Topic Collections Related Article

Thrombospondin in the eye

Correspondence to:
Correspondence to:
Dr Jay M Stewart University of California
San Francisco, Department of Ophthalmology, 10 Koret Way, K301, San Francisco, CA 94143-0730, USA; ne62@yahoo.com

Keywords: thrombospondin; age related macular degeneration; extracellular matrix; Bruch’s membrane

The first 150 words of the full text of this article appear below.

Research into the pathophysiology of age related macular degeneration (AMD) has advanced at a rapid rate in recent years. To see the pace of progress, one need only pick up any issue of a major ophthalmic journal or attend a poster session at an ophthalmic society meeting. Efforts are under way to learn more about the ageing of Bruch’s membrane, drusen formation, and angiogenesis in choroidal neovascularisation (CNV). And it’s beginning to pay off: our understanding of these mechanisms has led to some promising new treatments, particularly in the area of angiogenesis.

In the case of CNV, much of the focus lately has been on pro-angiogenic proteins such as vascular endothelial growth factor (VEGF). Treatment strategies that target pathologically elevated levels of VEGF are easy to understand: they try to block or reduce a known stimulus for the growth of CNV. Some early successes have been . . . [Full text of this article]

Related Article

Impaired expression of thrombospondin-1 in eyes with age related macular degeneration

K Uno, I A Bhutto, D S McLeod, C Merges, and G A Lutty
Br. J. Ophthalmol. 2006 90: 48-54. [Abstract] [Full Text] [PDF]