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The use of intravitreal triamcinolone in ophthalmology continues to increase. A number of indications for its use have now been documented. One of the significant side effects of it is non-infectious endophthalmitis. Maia and coworkers in a retrospective study document that this complication (non-infectious endophthalmitis) was significantly more likely to occur when triamcinolone was used with preservatives than without. They suggest that triamcinolone should be used without preservatives.
See pages 1099 and 1122
Ophthalmologists are well aware of the vascular changes that occur in the retina as the result of diabetes. Recently evidence has accumulated that damage to neural and glial cells may occur in the retina even in the absence of significant retinopathy. Verbraak and coworkers measured the retinal thickness in a group of diabetic patients with minimal retinopathy. Paracentral retinal thickness was significantly decreased in these patients suggesting that intraretinal neural tissue loss is an early stage of diabetic ocular pathology.
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