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Macular pseudoholes and lamellar holes
Differentiation between macular pseudoholes and lamellar holes can be difficult. 50 eyes of 46 consecutive patients diagnosed by OCT as having a foveal defect with residual retinal tissue were reviewed. Eyes classified as having pseudoholes (28) had macular centres and perifoveal retinas significantly thicker than the 22 eyes with lamellar macular holes. The corresponding corrected autofluorescence (AF) images were then evaluated. None of the control eyes showed foveal AF. Bottoni et al observed that AF imaging is superior to OCT data when differentiating between macular pseudoholes and lamellar holes, as presence of foveal AF is indicative of foveal tissue loss and, therefore, is diagnostic of a lamellar macular hole.
See pages 635
Autofluorescence of choroidal melanoma
Shields et al describe the autofluorescence features of choroidal melanoma in 51 consecutive patients. The choroidal melanoma showed intrinsic hypoautofluorescence (39%), isoautofluorescence (6%) and hyperautofluorescence (55%). Related RPE hyperplasia and atrophy showed hypoautofluorescence, drusen, RPE detachment and subretinal
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