© 2004 BMJ Publishing Group Ltd
LETTER
Exenteration of invasive conjunctival squamous cell carcinoma
1 Department of Ophthalmology, Julius Maximilians University Würzburg, Germany
2 Institute of Pathology, Julius Maximilians University Würzburg, Germany
Correspondence to:
Correspondence to:
Dr R Guthoff
Universitäts-Augenklinik, Josef-Schneider-Strasse 11, 97080 Würzburg, Germany; r_guthoff@yahoo.de
Accepted 7 December 2003
Keywords: exenteration; p53; squamous cell carcinoma; conjunctiva; human papillomavirus
| The first 150 words of the full text of this article appear below. |
Ocular surface squamous neoplasia (OSSN) includes conjunctival intraepithelial neoplasia with dysplasia, carcinoma in situ and conjunctival squamous cell carcinoma (SCC). Beside ultraviolet B irradiation identified as an risk factor, OSSN is associated with human papillomavirus type 16 and 18 (HPV-16, HPV-18).1–5 The exact role and possible prognostic value of p53 overexpression is unclear and little is known about its expression during the development of conjunctival SCC.
A 75 year old man was referred with a 10 year history of a conjunctival mass of the left eye with visual acuity of hand movement. Previous biopsies had revealed conjunctival dysplasia. On examination, the tumour of the ocular and tarsal conjunctiva of the lower lid covered the entire corneal surface (fig 1A
).
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Figure 1 Patient 1. (A) Extensive papillomatous tumour, subtotally covering the corneal surface of the left eye. Nodular thickening of the lower eyelid indicates eyelid involvement. (B) Histological appearance. Papillomatous pattern of | |||||||||
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