This Article Full Text Full Text (PDF) All Versions of this Article: bjo.2007.127860v1 92/6/747    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Google Scholar Articles by Pan, Y Articles by Lim, J I PubMed PubMed Citation Articles by Pan, Y Articles by Lim, J I Topic Collections Relevant Article

Primary transpupillary thermotherapy for small choroidal melanomas

¹ Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA
² Doheny Retina Institute of Doheny Eye Institute, Los Angeles, CA, USA
³ Eye and Ear Infirmary, UIC Eye Center, University of Illinois at Chicago, IL, USA

Correspondence to:
Professor J I Lim, Eye and Ear Infirmary, University of Illinois, UIC Eye Center, 1855 W. Taylor Street, Mail Code 648, Chicago, IL 60612, USA; jennylim{at}uic.edu

Aims: To determine visual and anatomic outcomes following transpupillary thermotherapy (TTT) as a primary treatment for small choroidal malignant melanomas.

Methods: 20 patients with small choroidal melanomas who underwent primary TTT at our institution were retrospectively reviewed. Patients with choroidal melanomas posterior to the equator with a basal diameter less than 12 mm and thickness less than 3.5 mm were included if the lesion had documented growth or clinical risk factors for growth.

Results: Thirteen women and seven men (mean age: 65 years, range: 41–85 years) underwent TTT. The mean preoperative tumour thickness was 1.81 mm (range: 0.78–3.40 mm). The mean follow-up time after TTT was 44.6 months (range: 11–108 months, median: 47.5 months). After a mean of 2.15 primary TTT sessions (range: 1–4), tumour regression without recurrence was attained in 11 (55%) of 20 cases. Five of the nine remaining tumours with recurrence were successfully treated with additional TTT. One patient declined further TTT and underwent enucleation. Three other tumours had recurrence after repeat TTT. The mean time to recurrence after initial TTT was 20.8 months (range: 8–37 months). The mean time to recurrence after repeat TTT was 35 months (range: 5–69 months). There was no tumour-related metastasis or death.

Conclusions: Tumours treated with TTT have significant recurrence rates. Although tumour control may ultimately be achieved with TTT, close monitoring of these tumours is necessary, since repeat TTT or alternative therapies may be required.

Ethics approval: This study was approved by the institutional review board of the University of Southern California, and the study was performed in accordance with Health Insurance and Portability and Accountability Act regulations.

Relevant Article

Primary transpupillary thermotherapy of "small" choroidal melanoma: is it safe?

Arun D Singh, Tero Kivelä, Stefan Seregard, Dennis Robertson, and James F Bena
Br. J. Ophthalmol. 2008 92: 727-728. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				A. D Singh, T. Kivela, S. Seregard, D. Robertson, and J. F Bena Primary transpupillary thermotherapy of "small" choroidal melanoma: is it safe? Br. J. Ophthalmol., June 1, 2008; 92(6): 727 - 728. [Full Text] [PDF]