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The efficacy and safety of posterior scleral reinforcement using genipin cross-linked sclera for macular detachment and retinoschisis in highly myopic eyes
  1. Shuang-Qian Zhu,
  2. Lin-Yan Zheng,
  3. An-Peng Pan,
  4. A-Yong Yu,
  5. Qin-Mei Wang,
  6. An-Quan Xue
  1. The Eye Hospital of Wenzhou Medical University, Wenzhou, China
  1. Correspondence to An-Quan Xue, The Eye Hospital of Wenzhou Medical University, 270 Xueyuan West Road, Wenzhou, Zhejiang 325000, China; xueanquandoctor{at}163.com

Abstract

Background/aims To evaluate the efficacy and safety of posterior scleral reinforcement (PSR) using genipin cross-linked sclera as the material to treat macular detachment and retinoschisis, both without macular hole, in highly myopic eyes.

Methods Twenty-one patients with highly myopic eyes (24 eyes) with macular detachment and retinoschisis were treated sequentially with genipin cross-linked PSR and were followed for at least 1 year after surgery. The best-corrected visual acuity (BCVA), spherical equivalent (SE) power, axial length (AL), optical coherence tomography, and the complications were evaluated.

Results The mean SE decreased from −13.81±4.67 D preoperatively to −9.64±4.86 D postoperatively, while the improvement in the logMAR BCVA values was from 1.24±0.57 before surgery to 1.03±0.57 after surgery. The preoperative AL (29.73±2.31 mm) was decreased (28.08±2.08 mm) after the operation. The retina in 21 eyes (87.5%) was successful reattached and the macular detachment was significantly decreased in two eyes; a macular hole occurred in one eye.

Conclusions For at least a 1 year period of follow-up, PSR with genipin cross-linked sclera was safe and effective to treat macular detachment and retinoschisis in high myopia when a macular hole was not present. The reinforcement effect tended to be stabilised and maintained for 6 months after treatment.

  • Retina
  • Treatment Surgery
  • Macula

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Footnotes

  • Contributors S-QZ conceived the idea for the paper and wrote the manuscript. L-YZ and A-PP collected and analysed the data, and performed a literature search. A-QX conceived the idea for the paper and critically revised the manuscript. A-YY and Q-MW studied the design and data interpretation.

  • Funding The Science and Technology Plan Project of Wenzhou Science and Technology Bureau (Y20140552).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study was approved by the Ethics Committee of the eye hospital of Wenzhou Medical University. Signed informed consent that allowed use of the data for research was obtained from each participant.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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