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Clinical science
Incidence and survival of retinoblastoma in Taiwan: a nationwide population-based study 1998–2011
  1. Su-Yin Li1,2,
  2. Solomon Chih-Cheng Chen3,4,
  3. Ching-Fang Tsai3,
  4. Shew-Meei Sheu3,
  5. Jun-Jun Yeh1,2,5,
  6. Chong-Bin Tsai6
  1. 1Department of Family Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan
  2. 2Chia Nan University of Pharmacy and Science, Taiwan
  3. 3Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan
  4. 4Department of Pediatrics, School of Medicine, Medical College, Taipei Medical University, Taipei City, Taiwan
  5. 5Meiho University, Pingtung, Taiwan
  6. 6Department of Ophthalmology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan
  1. Correspondence to Dr Solomon C-C Chen, Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, No. 539, Zhongxiao Road., East District, Chiayi city 60002, Taiwan; solomon.ccc{at}gmail.com

Abstract

Objective To study the epidemiology of retinoblastoma in Taiwan from 1998 to 2011.

Design This was a retrospective population-based cohort study using the Taiwan National Health Insurance Research Database.

Results The present study included 154 patients (92 males, 62 females) with retinoblastoma and the documented overall retinoblastoma incidence was 1 in 17 373 live births without a notable trend over the study period. The incidence per million live births examined by gender was 65.8 for males and 48.5 for females. The age-specific sex ratio increased from 1.4 at age younger than 1 year to 3.0 above age 4 years. Enucleation was performed in 109 (70.8%) children with retinoblastoma, and it was more prevalent in males than in females (77.2% vs 61.3%, p=0.0335). Multivariate Cox regression analyses with adjustment for diagnostic age, sex, and birth year elucidated that enucleation was a significant factor associated with survival (OR 0.27, 95% CI 0.10 to 0.61).

Conclusions The incidence of retinoblastoma in Taiwan exhibited no marked trend over time. There were more cases of males than females and the male-to-female rate ratio increased with age. Survival outcome was significantly associated with the intervention of enucleation.

  • Epidemiology
  • Neoplasia
  • Child health (paediatrics)

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bjophthalmol-2015-307211

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