The outflow changes in 26 eyes were measured during the course of a positive provocative test with pilocarpine and phenylephrine. Three separate patterns of response occurred: (1) One dose of pilocarpine and phenylephrine produced an acute attack with a large reduction in outflow. (2) The first dose of pilocarpine and phenylephrine produced a fall in pressure and increase in outflow. The second dose reversed this effect and closed the angle. (3) The first dose of pilocarpine and phenylephrine increased pressure by an insignificant amount and decreased outflow. The second dose accentuated this response and produced an acute attack.
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