Article Text

PDF

Behaviour of untreated proliferative sickle retinopathy.
  1. P I Condon and
  2. G R Serjeant

    Abstract

    The development of ocular lesions in 313 patients with sickle cell disease followed up for periods of 1--8 years is described. Proliferative sickle retinopathy (PSR) was present on initial examination in 68 (12%) of 567 eyes and developed in a further 46 (8%) eyes during the study period. Spontaneous regression (autoinfarction) was present on initial examination in 33 (49%) eyes with PSR initially and developed in a further 45 (39%) eyes during the study. Development of PSR was more common in sickle cell-haemoglobin C (SC) disease, and autoinfarction appeared to occur more commonly in homozygous sickle cell (SS) disease. The two processes were delicately balanced, and some PSR lesions lasted less than a year before undergoing autoinfarction. Although the high prevalence of autoinfarction diminishes the clinical sequelae of PSR, blindness related to PSR occurred in 14/119 (12%) eyes. Autoinfarction closes the feeding vessels of PSR lesions more elegantly than, and without the complications associated with, photocoagulation. A greater understanding of factors involved in the progression and regression of PSR is relevant to defining the role of photocoagulation in this condition.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.