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Research Article
Penetration of timolol eye drops into human aqueous humour: the first hour.
  1. C. I. Phillips,
  2. R. S. Bartholomew,
  3. A. M. Levy,
  4. J. Grove and
  5. R. Vogel

    Abstract

    Samples of aqueous humour were removed from 26 eyes at the start of cataract extraction. Two drops of timolol 0.5% had been instilled into the conjunctival sac 12-71 minutes before operation. Analysis by gas chromatography showed a mean timolol concentration of 55.46 ng/mg, with a range of 8 to 100 ng/mg.

    https://doi.org/10.1136/bjo.69.3.217

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