The intraocular fluids and sera from three patients with acute retinal necrosis (ARN) and from 120 age-matched controls were tested for the presence of antibodies to herpes simplex virus type I (HSV-I). Antibodies to HSV-I were detected in both intraocular fluids and sera of two cases, and in intraocular fluids alone in one case of ARN. Among 120 control patients undergoing routine intraocular surgery antibodies to HSV-I were detected in the sera of 85 (79.2%) but in the intraocular fluids of only two (1.7%). The presence of antibody within the eye may indicate local antibody production, antibody sequestration within the eye, or damage to the blood ocular barrier.
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