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Hydrogel keratophakia: a microkeratome dissection in the monkey model.
  1. W H Beekhuis,
  2. B E McCarey,
  3. G O Waring and
  4. G van Rij

    Abstract

    High water content intracorneal implants were fabricated from Vistamarc hydrogel (Vistakon, Inc.) at 58%, 68%, and 72% water content and a range of powers from +7.25 to +17.00 dioptres. The Barraquer microkeratome technique was used to implant the lens at 59.0 +/- 9% (+/- SD) depth in the corneas of 14 rhesus monkey eyes. The contralateral eye served as a control. Three eyes were lost to the study because of complications. The remaining 11 animals were followed up for 51 +/- 2 weeks with the refractive yield being 118 +/- 34% and the keratometric yield being 92 +/- 30%. The measured and theoretically expected refractive changes have a linear regression line correlation coefficient of 0.74, whereas the respective keratometric data had a correlation coefficient of 0.04. The measured refraction became stable within 2 to 3 dioptres after 20 postoperative weeks. The hydrogels were well tolerated within the corneal tissue. There was a minimum of interface problems except along the edge of the implant. Implants with abruptly cut edges versus a fine wedge tended to have more light scattering collagen at the implant margin.

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