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Cobalt plaque versus enucleation for uveal melanoma: comparison of survival rates.
  1. K S Adams,
  2. D H Abramson,
  3. R M Ellsworth,
  4. B G Haik,
  5. M Bedford,
  6. S Packer,
  7. J Seddon,
  8. D Albert and
  9. L Polivogianis
  1. Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021.

    Abstract

    Two hundred and twenty-three patients treated by cobalt plaque for uveal melanoma were compared with 416 patients treated by enucleation for uveal melanoma in terms of patient survival. The median follow-up time for the patients treated by cobalt plaque was 4.3 years. Kaplan-Meier survival curves were calculated up to five years following treatment based on time to tumour-related deaths. Cox's proportional hazards multivariate analysis was performed to determine which variables were related to melanoma-related deaths while controlling for age, size, and location of the tumours. Statistically significant predictive factors were location of tumour and largest tumour dimension. There was not a statistically significant difference in survival between patients treated by cobalt plaque and those treated by enucleation.

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