Br J Ophthalmol 73:286-288 doi:10.1136/bjo.73.4.286
  • Research Article

Visual toxicity of synthetic retinoids.

  1. R D Brown and
  2. C E Grattan
  1. Birmingham and Midland Eye Hospital.


      Twelve patients treated with isotretinoin, a synthetic vitamin A analogue, were assessed before, during, and after therapy. Significant falls occurred in the amplitude of the a waves of the scotopic electroretinogram.