rss
Br J Ophthalmol 73:323-327 doi:10.1136/bjo.73.5.323
  • Research Article

T and B cell reactivity to extraocular and skeletal muscle in Graves' ophthalmopathy.

  1. A P Weetman,
  2. P Fells and
  3. B Shine
  1. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital.

      Abstract

      We have sought human eye muscle membrane binding antibodies in patients with Graves' ophthalmopathy using an enzyme-linked immunoassay. Antibodies were found in patients with thyroid autoimmunity irrespective of eye signs, and binding correlated closely (r = 0.94) with binding to skeletal muscle, showing that these antibodies are not site-specific. T cells from patients with thyroid autoimmunity proliferated in response to eye muscle, but again this was not specific for eye muscle or the presence of ophthalmopathy. No single antigen was responsible for inducing proliferation. These results fail to confirm a recent report of eye muscle membrane binding antibodies in a high proportion of patients with ophthalmopathy, and suggest instead that T and B cell autoreactivity to striated muscle antigens is a frequent feature of autoimmune thyroid disease, unlikely to be directly related to eye disease.

      Register for free content


      Free sample
      This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
      View free sample issue >>

      Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

      Navigate This Article