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Uveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis.
  1. C. M. Antle,
  2. K. F. Damji,
  3. V. A. White and
  4. J. Rootman
  1. Department of Pathology, Vancouver General Hospital, British Columbia, Canada.

    Abstract

    A case of uveal malignant melanoma and contralateral optic nerve glioma is described in a 53-year-old Caucasian male with multiple uveal melanocytic hamartomas and neurofibromatosis. The eye was enucleated, and histologically the melanoma was found to consist of 70% epithelioid cells, with many bizarre, multinucleated forms. CT scan demonstrated a non-enhancing, fusiform enlargement of the contralateral optic nerve with enlargement of the optic canal and intracranial extension. This combination of tumours has not previously been reported in a patient with neurofibromatosis and serves to emphasise the common neuroectodermal origin of tumours in this autosomal dominant condition.

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