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Premalignant melanosis of the conjunctiva and the cornea in xeroderma pigmentosum.
  1. A D Paridaens,
  2. A C McCartney and
  3. J L Hungerford
  1. Department of Pathology, Institute of Ophthalmology, London.


    Xeroderma pigmentosum is a rare autosomal recessive dermatosis. The neoplastic changes in sunlight-exposed areas of the skin and eyes may be related to the impaired replication of ultraviolet radiation-damaged DNA. A 38-year-old Greek woman is reported with a mild form of xeroderma pigmentosum and primary acquired melanosis with atypia of her right limbal conjunctiva and cornea. The development of this precursor of conjunctival malignant melanoma in a xeroderma pigmentosum patient may support the putative role of sunlight exposure in malignant transformation of conjunctival melanocytes.

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